The newly approved medicines in 2024 from Massachusetts companies range from a schizophrenia drug to a gene therapy for ...

In 2024, multiple drugs received complete response letters (CRLs), sometimes unrelated to the safety and efficacy of the drug ...

Defects in the cholinergic signaling pathway have been shown to underlie Alzheimer’s disease and its symptoms.

This is an important study using a combination of optogenetics and calcium imaging to provide insight into the function of the cholinergic input to the prelimbic cortex in probabilistic spatial ...

Can Heart Heal Itself?A research team co-led by a physician-scientist at the University of Arizona College of Medicine – ...

The efficacy of individual treatment approaches with contrasting cholinergic and glutamatergic mechanisms of action prompted investigation of the effects of targeting both systems for the ...

Glucagon-like peptide-1 (GLP-1) receptor agonists have quickly become some of the most ubiquitous drugs in the United States. Though they were originally indicated to treat diabetes, and to assist ...

Department of Resources Science of Traditional Chinese Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, P. R. China ...

This treatment is a new class of medication that targets cholinergic receptors instead of dopamine receptors in the brain. The FDA based its approval on the findings of two identical clinical trials.

The importance of the brain renin-angiotensin system in cardiovascular function is well accepted. However, not knowing the precise source of renin in the brain has been a limitation toward a complete ...