Accordingly, although there is presently no “cure” for Alzheimer’s disease, a large number of potential therapeutic interventions have emerged that are designed to correct loss of presynaptic ...

Drugs acting on the cholinergic system can improve or worsen cognitive abilities, and their effects are particularly pronounced in frail elderly individuals and patients with Alzheimer disease.

Although compounds with a combined cholinergic–glutamatergic action have been trialed, none has yet been successful in the later stages of development (Table 4). Consequently, combination ...

Mid-level intoxication with some organophosphates initially produce marked cholinergic symptoms due to muscarinic receptor stimulation. Nicotinic receptor blockage occurs within 1–3 days ...

In 2024, multiple drugs received complete response letters (CRLs), sometimes unrelated to the safety and efficacy of the drug ...

Methods: A MedLine search was performed to identify studies that assess the clinical characteristics of PD. Search terms included “Parkinson’s disease”, “diagnosis” and “signs and symptoms”. Results: ...

However, other types of dermatitis and eczema have more specific names, different symptoms, and other features ... other types of dermatitis, including cholinergic urticaria (heat hives) and ...

The first symptoms of not eating can include fatigue, difficulty concentrating, and nausea, in part due to hypoglycemia (low blood sugar). As time goes on, more severe symptoms like slurred speech, ...

You may also develop certain uncomfortable symptoms. Everyone knows the classic signs of pregnancy. You’ve missed your period. Your breasts are tender. You have morning sickness. And you’re ...

Human beings are a bit of a puzzle. There’s a paradoxical desire for connection with others while also staying unique. On the ...

You can develop an imbalance due to natural hormonal transitions or certain medical conditions. This can lead to a variety of symptoms such as menstrual irregularities, skin changes, and weight ...