Select the journal/section where you want your idea to be submitted: The regulation of gene expression in eukaryotes is controlled by many factors, among which the composition and spatial organization ...

Chromatin organization strengthens DNA for mechanically stressful processes like mitosis, helps protect DNA from damage and is important in the control of gene expression and DNA replication.

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Chromatin structure describes the physical ... Three-dimensional genome organization is important for transcription regulation. Here the authors show that microRNA 9 mediates the formation of ...

Chromatin is a combination of DNA and proteins that makes up the chromosomes in the cells of humans and other higher ...

Now, a new research project funded by the National Institutes of Health and led by a malaria expert at the University of ...

Breast cancer cells exhibit organotropism during metastasis, showing preferential homing to certain organs such as bone, lung, liver, and brain. One potential explanation for this organotropic ...

In addition, transcripts with higher abundance tend to enrich at more TFBS. Overall, the study highlights the role of RNase-inaccessible caRNAs in chromatin regulation and provides insight into their ...

Since 2014, she leads her own research team in Weill Cornell Medicine in New York studying the critical interplay between TFs, 3D chromatin organization and transcription during cell cycle or cell ...

引言细胞命运的转换是现代生命科学和医学领域中最具革命性的话题之一。通过精准操控细胞命运，研究人员可以将一种成熟的细胞类型重编程为另一种完全不同的细胞类型，这种过程不仅揭示了生命系统的可塑性，更为再生医学、疾病建模和个性化治疗开辟了新的可能性。然而，重 ...

In the United States, a qualified charitable organization is known as a 501(c)(3) organization, referring to the portion of the Internal Revenue Code (IRC) that deals with the tax treatment of ...

In the 3D space, mammalian genome is folded and packed in a highly organized fashion. Besides the well-known chromatin relaxation and compaction associated with "open" and "closed" chromatin, DNA also ...