When methylation affects CpG islands, methyl-binding proteins trigger a silencing cascade (activity illustrated by green stars) whereby histone H3K9 is sequentially deaceylated and then methylated ...

Not all genes are active at all times. DNA methylation is one of several epigenetic mechanisms that cells use to control gene expression. This straightforward experiment demonstrated that it was ...

The latter is called an epigenetic alteration. While cytosine methylation is a healthy process, methylation of promoter CpG islands has also been shown to be a critical hallmark in many cancer cells.

Developmentally programmed 3’ CpG island methylation confers tissue- and cell-type specific transcriptional activation. Mol Cell Biol. 2013; 33 (9): 1845-58. Pubmed PMID: 23459939 PMCID: PMC3624169 ...