总的来说，本研究证明了FTO介导的病理过程在具有侵袭性生长激素分泌的垂体神经内分泌肿瘤中的重要性，并揭示了新的治疗靶点。此外，由FTO调节的连接复合体相关基因可以作为分类生长激素分泌垂体神经内分泌肿瘤的创新因子。

The sequencing of the human genome at the turn of the 21st century was heralded as a monumental scientific achievement ...

Indeed, mammalian genomic DNA remains immunologically inert even after demethylation 12, which suggests that some additional factors may be responsible for the immunostimulatory properties of ...

1 Additionally, during gametogenesis, not all methylated cytosines (5-mC) in primordial germ cells undergo demethylation; a significant proportion of these epigenetic marks exhibit resistance to ...

For human tissues, prior experimental manipulations are impractical, and genomic alterations are employed. Somatic mutations mark subclones and their fates can be reconstructed with DNA sequencing ...

They found that ischemic injury induces astrocytes to modify their methylome to a stem cell state, involving the methylation ...

Diverse frequencies among individuals from various racial and ethnic backgrounds can result in modified therapeutic strategies. Whereas the CYP2D6*4 allele is present at a high frequency in ...

Samples from 15 patients also showed that demethylation had occurred in tumours after treatment, while RNA analysis confirmed that inflammation was taking place in the tumour that wasn’t present ...

KEY POINTS A 65-year-old woman presented to the emergency department with an 8-day history of progressive leg weakness and ...

What is Known About the Estrogen Deficiency of Menopause & Specific Autoimmune Diseases It is known that many natural, pathological and therapeutic conditions can change serum estrogen levels ...