RNA methylation and demethylation regulate gene transcription, pre-mRNA splicing, mRNA stability, protein translation, tumor initiation and progression. Small molecule compound inhibitors of RNA ...

Diverse frequencies among individuals from various racial and ethnic backgrounds can result in modified therapeutic strategies. Whereas the CYP2D6*4 allele is present at a high frequency in ...

总的来说，本研究证明了FTO介导的病理过程在具有侵袭性生长激素分泌的垂体神经内分泌肿瘤中的重要性，并揭示了新的治疗靶点。此外，由FTO调节的连接复合体相关基因可以作为分类生长激素分泌垂体神经内分泌肿瘤的创新因子。

KEY POINTS A 65-year-old woman presented to the emergency department with an 8-day history of progressive leg weakness and ...

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Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon, Korea ...

Objectives An interferon (IFN) gene signature (IGS) is present in approximately 50% of early, treatment naive rheumatoid arthritis (eRA) patients where it has been shown to negatively impact initial ...

For human tissues, prior experimental manipulations are impractical, and genomic alterations are employed. Somatic mutations mark subclones and their fates can be reconstructed with DNA sequencing ...