Gain Therapeutics' GT-02287 shows promise in treating Parkinson's disease, with positive results and potential for market ...

Nutrition encompasses a crucial influence on health and diseases, notably within the domain of cancer, where it intersects significantly with metabolic ...

This study will be of relevance to researchers interested in metabolism, fatty liver disease, and the biology of trace elements. Heterozygous loss-of-function mutations in SLC39A5 associated with ...

we expected that venetoclax would have a direct impact on CAR T cell populations through mitochondrial or endoplasmic reticulum (ER) protein interaction and localization," says presenting author ...

Nearly one-third of all human proteins must be transported to the endoplasmic reticulum (ER ... which are vital for their structure and function. Disruptions in protein translocation to the ...

Approximately one-third of the newly synthesized proteome enters the endoplasmic reticulum (ER), a process crucial for generation of the endomembrane system in eukaryotic cells. The Sec61p (or ...

The study was carried out as part of the “SCALE - Subcellular Architecture of Life" cluster initiative. The endoplasmic reticulum functions as a reservoir for calcium and carbohydrates and also serves ...

FRANKFURT. The endoplasmic reticulum functions as a reservoir for calcium and carbohydrates and also serves as the site for the synthesis of various hormones. Cells adjust the expansion and ...

Using Saccharomyces cerevisiae, we identified the first short linear sequences that function as degrons from the endoplasmic reticulum (ER) lumen. We show that when these degrons are transferred to ...