Objective Bile acids are important regulators of intestinal physiology, and the nuclear bile acid receptor, farnesoid X receptor (FXR), is emerging as a promising therapeutic target for several ...

xenobiotic compounds and microbial byproducts can maintain critical gut immunity by inducing antimicrobial gene expression. FXR: Farnesoid X receptor; VDR: Vitamin D receptor; RXR: Retinoid X ...

The Swiss pharma said it is to begin a phase IIb trial of one of its Farnesoid X receptor (FXR) agonists in combination with Allergan’s cenicriviroc in NASH. A group of around half a dozen ...

Therapeutic strategies targeting this pathway include peroxisome proliferator-activated receptor (PPAR) agonists, bile acid-farnesoid X receptor (FXR) agonists, and de novo lipogenesis (DNL ...

Non-alcoholic fatty liver disease (NAFLD), recently reclassified as metabolic dysfunction-associated steatotic liver disease ...

Quick Facts LXRα (nuclear receptor subfamily 1, group H, member 3), Identifiers ...

GLP-1 receptor agonists are a non-insulin type 2 diabetes medication. GLP-1 agonists help to lower blood sugar and aid in weight loss. Drugs in this class include Byetta (exenatide), Victoza ...

Of these, the following five comprise 35% of the pipeline molecules: "Metabolic hormones, such as GLP-1 or GIP receptor agonists, farnesoid X receptor (FXR) agonists, fibroblast growth factor (FGF ...

including the oxysterol receptors (LXRs), the bile acid receptor (FXR), and the dafachronic acid receptor (DAF-12) that is found in nematodes and governs the dauer diapause. He has received several ...

On Friday, the agency's Gastrointestinal Drugs Advisory Committee members voted 10-1 (with three abstentions) that the ...