"Gaining functional information on the genes and proteins associated with cancer is an important step toward better understanding the disease and identifying potential therapeutic targets," said ...

“Our approach to gain functional insights into these genes and proteins involved using machine learning to develop a network mapping their functional relationships,” said Zhang, member of Baylor’s Dan ...

Using proteomics analyses, researchers can better understand the function of those genetic features and how they change over time. What methods do researchers use to analyze the proteome? Some common ...

A microarray is a set of samples, for example DNA, RNA or proteins, arranged on a solid substrate or chip, such as a glass slide or silicon film, that is used in high throughput experiments.

Further studies are now needed to investigate these control proteins. Despite these studies, the degree to which regulation by AS is conserved or whether AS plays any role in non-mammalian stem cells ...

Tumor suppressor p53 is the most frequently mutated gene in tumors. Many mutant p53 (mutp53) proteins promote tumorigenesis through the gain-of-function (GOF) mechanism. Mutp53 proteins often ...

However, as exemplified above, alteration of target protein levels may result in compensatory changes in other components of a system and the perturbation might not provide the expected result.

Conventional protein microarrays have evolved as a promising proteomic technology with great potential for protein expression profiling in health and disease. In this study, Akada et al.

No writing assistance was utilized in the production of this manuscript. Reverse-phase protein microarray was used to evaluate protein levels and activation/phosphorylation status of HER family ...