Doctors biopsied it to understand the type of cancer it was and discovered it was something called a germ cell tumor, a cancer that forms from nascent reproductive cells. Pastuovic said his tumor ...

Accumulating evidence indicates that epigenetic modifiers have key roles in genome-wide reprogramming and activation and repression of specific genes during mammalian germ-cell development.

To address this gap, researchers analyzed gene expression within individual tumor cells. This study reports the molecular features and interactions of tumor and immune cells associated with two ...

In vivo, tumor-bearing mice that had the HIF1α-deleted in T cells did not respond to ICB therapy. The researchers then showed a way to overcome that resistance to ICB therapy.

In 2023, Penn State biomedical engineering researchers developed an ultrasound imaging technique to visualize the movement of a type of immune cell called a macrophage, which works to heal wounds and ...

Introduction: The abscopal effect, a systemic anti-tumor response triggered by localized treatment ... that could be construed as a potential conflict of interest. FUS, focus ultrasound; DAMPs, damage ...

Introduction: T cell Antigen Coupler (TAC) T cells harness all signaling subunits of endogenous T cell receptor (TCR) to trigger T-cell activation and tumor cell lysis, with minimal release of ...