Selumetinib sulfate is under clinical development by AstraZeneca and currently in Phase II for Peripheral Nerve Sheath Tumor (Neurofibrosarcoma ... relapsed or refractory diffuse large B-cell lymphoma ...

Background Differentiating arteritic anterior ischaemic optic neuropathy (A-AION) due to giant cell arteritis (GCA) from non-arteritic anterior ischaemic ... Two radiologists blinded to clinical data ...

The single-cell analysis revealed a diverse range of cell types within the tumor microenvironment (TME), including tumor cells, immune cells, and fibroblasts, with varying proportions across cases.

However, their effectiveness has plateaued due to therapeutic resistance that renders tumor-infiltrating lymphocytes ... Additionally, pharmacologic inhibition of T cell glycolysis under hypoxia ...

Introduction: T cell Antigen Coupler (TAC) T cells harness all signaling subunits of endogenous T cell receptor (TCR) to trigger T-cell activation and tumor cell lysis, with minimal release of ...

Having a larger amount of LPCs in the bloodstream aids cancer cell replication, thus helping tumors grow. “When you eat an excessive amount of food, your body converts it into fat,” Patti ...

For the first time, researchers have used lab-grown organoids created from tumors of individuals with glioblastoma (GBM) to accurately model a patient's response to CAR T cell therapy in real time.

The researchers created organoids from the tumors of patients with recurrent glioblastoma who underwent surgery as part of a Phase I clinical trial for a dual-target CAR-T cell therapy.

The Extremely Large Telescope is currently under construction, with the most recent milestones including progress made with building the dome, central structure and the base for the primary mirror ...