Background: The pathogenesis of daytime hypercapnia (PaCO 2 ≥ 45 mm Hg) may be directly linked to the existence of obstructive sleep apnea syndrome (OSAS) per se, although only some patients ...

This agent acts either by stimulating the respiratory ... hypercapnia; the remaining 4 had moderate elevations of arterial carbon dioxide tension at rest but no evidence of congestive heart ...

with severe chronic obstructive pulmonary disease (Global Initiative for Chronic Obstructive Lung Disease [GOLD] stage IV D), as well as chronic hypoxemic and hypercapnic respiratory failure.