One such pathway, the hypoxic response pathway, is activated by reduced local oxygen concentrations at the tumor site. Hypoxia-driven gene and protein changes enhance epithelial-to-mesenchymal ...

Immune checkpoint blockades, or ICBs, have revolutionized treatment for various advanced cancers. However, their ...

"However, it has been unknown, under hypoxia, whether and how HIF1α regulates IFN-γ induction and glycolysis in T cells." The UAB researchers found that HIF1α-glycolysis is indispensable for IFN-γ ...

Researchers identify key regulator that induces cancer-killing capacity in T cells under hypoxia: Birmingham, Alabama Monday, December 16, 2024, 17:00 Hrs [IST] Immune checkpoint ...

Immune checkpoint blockades, or ICBs, have revolutionized treatment for various advanced cancers. However, their ...

“However, it has been unknown, under hypoxia, whether and how HIF1α regulates IFN-γ induction and glycolysis in T cells.” The UAB researchers found that HIF1α-glycolysis is indispensable for IFN-γ ...

At this point, descent to lower altitude or treatment in a portable pressure chamber and administration of oxygen are critical to prevent hypoxia and life-threatening high-altitude hypoxic brain ...

These studies in fetoplacental vessels showed that acute hypoxia-induced vasoconstriction of fetoplacental arteries reduces placental perfusion. However, capillary network expansion in the chronically ...

The UAB researchers found that HIF1α-glycolysis is indispensable for IFN-γ induction in hypoxic T cells. HIF1α is a subunit of HIF, or hypoxia-inducible factor, that is known to play a crucial ...