Introduction: T cell activation requires T cell receptor (TCR) engagement by its specific ligand ... in the presence of 100 U/ml of human IL-2 and soluble anti-CD28 antibody (BD Biosciences, Clone: 37 ...

a biotech company pioneering the screening, discovery, and development of small molecule ligands that modulate orphan or unexplored members of the nuclear receptor ... TNFα and IL-12/IL-23 ...

Here, we provide an optimized approach for TCR clone selection that capitalizes on recent technological advances in the single cell sequencing field that combine analysis of cellular heterogeneity of ...