The formation of pores by a particular protein, gasdermin D, plays a key role in inflammatory reactions. During its activation, an inhibitory part is split off. More than 30 of the remaining protein ...
Overall, the evidence points to a role for SIRT1 as a bridge between metabolism and inflammation, making it a potential therapeutic target in metabolic and immune diseases; however, the specific role ...
Keywords: inflammation, myocardial infarction, coronary artery disease, heart failure, cardiovascular disease Important Note: All contributions to this Research Topic must be within the scope of the ...
Inflammasomes, large multiprotein complexes of the innate immune system, activate and control inflammatory reactions in our body ... Antagonistic nanobodies implicate mechanism of GSDMD pore formation ...
As a critical care doctor, I have long considered inflammation a necessary evil, the mechanism through which our bodies sound an alarm and protect us from threat. But a growing body of research ...
Our studies have demonstrated the involvement of the complex in the regulation of cholesterol metabolism and transport, in anti-inflammatory crosstalk mechanisms, in adipose tissue inflammation and ...