A recent simulation study published in the journal Scientific Reports analyzed representative data of over two million outpatients in Germany, in which the researchers reported that a combination ...

Mechanisms of action Ezetimibe's inhibition of cholesterol absorption results in depletion of the cholesterol in chylomicrons, which in turn leads to diminished hepatic cholesterol and ...

Mechanisms of action Ezetimibe's inhibition of cholesterol absorption results in depletion of the cholesterol in chylomicrons, which in turn leads to diminished hepatic cholesterol and ...

Ezetimibe reduces LDL cholesterol levels, and niacin raises HDL cholesterol levels; however, no previous studies have described the use of these two drugs in combination.

The cholesterol-lowering drug ezetimibe (Zetia) has been associated with muscle aches and rhabdomyolysis when used on its own and in combination with statins. Other factors that increase the risk ...

More than a quarter of Americans over the age of 40 are taking a statin. But what happens if you are statin-intolerant?

“Statins are marvelous drugs. They have probably saved as many ... Alternatives include ezetimibe, but it’s only effective in some people. PCSK9 inhibitors are powerful but need to be injected ...

Addition of mipomersen (given once a week by injection) to the lipid-lowering therapy currently used by the patients (such as statins and ezetimibe) resulted in an average reduction in LDL ...

Compared with the combination of statin and ezetimibe, replacing ezetimibe with Praluent cost $997 000 per QALY. "We do think these drugs are useful to patients,” Kazi added, “and cost is a ...

This drug candidate in Japan is expected to become a new treatment option for hypercholesterolemic patients with insufficient response to statins or statin intolerance. NEXLIZET and NEXLETOL are ...