The University of Michigan has identified proteolysis targeting chimeric (PROTACs) compounds comprising cereblon (CRBN) ligands covalently bonded to a CREB-binding protein (CREBBP; CBP) and/or histone ...

One important example are histones, which are needed at a constant histone-to-DNA stoichiometry. Here we show that budding yeast achieves histone homeostasis in different nutrients through a ...

Five families of histones are found in eukaryotic cells, namely, H1/H5, H2A, H2B, H3, and H4. H1 and H5 histones (linker histones) lock the DNA into place by binding the DNA entry and exit sites and ...

and tumorigenesis due to its unique linker and macro domains. The histone chaperone Facilitates Chromatin Transcription (FACT) can clear macroH2A from specific locations on the chromatin ...