The discovery of histone lysine demethylases has provided the opportunity for a detailed exploration of the regulation of histone-methylation dynamics. Although the focus of the past few years has ...

中国农业大学等处的研究人员发表了题为“Dense Chromatin Activates Polycomb Repressive Complex 2 to Regulate H3 Lysine 27 Methylation ”的文章，揭示出染色质的紧密程度能调节组蛋白H3K27甲基化酶复合体PRC2的催化活性，从而影响基因转录，这有助于解析基因转录调控以及基因沉默 ...

The sequencing of the human genome at the turn of the 21st century was heralded as a monumental scientific achievement ...

Chemical changes to histones, the proteins that help to pack and organize DNA inside cells, play a key role in determining ...

(This work was highlighted by Elife Digest) Chen S, Kapilashrami K, Senevirathne C, Wang Z, Wang J, Linscott JA, Luo M. Substrate-Differentiated Transition States of SET7/9-Catalyzed Lysine ...

Please Contact Dr. Guiliang Tang. Dr. Tang conducted his graduate research on the catabolic pathway of the essential amino acid lysine in the laboratory of Dr. Gad Galili at the Weizmann Institute of ...

The Luo Lab is interested in developing and leveraging novel approaches at the interface of chemistry and biology to annotate functional roles of epigenetic modulators. Epigenetic regulation is ...

In fact, biological outcomes are often due to physical interactions between proteins that are so highly selective that seemingly minor chemical modifications (i.e. methylation, acetylation or ...

Among the available options, lysine clonixinate (LC) and naproxen sodium (NS) have proved effective in migraine. The aim of this study was to compare the efficacy and tolerability of oral ...

This valuable report describes the changing antiviral activity of IFIT1 across mammals and in response to distinct viruses, likely as a result of past arms races. One of the main strengths of the ...