GABARAPs interact directly with NUFIP2 and G3BP1 whereas Atg8ylation is needed for their recruitment to damaged lysosomes. At the lysosome, NUFIP2 contributes to MTOR inactivation together with LGALS8 ...

Notably, the emergence of SMC-derived luminal myofibroblasts—in both mice and patients with KD, Takayasu’s arteritis and Giant Cell arteritis—coincided with activation of the mechanistic target of ...

Mishima, Y., and Schaub, jun., F. F., Proc. Twelfth Intern. Cong. Dermatol. Excerpta Med. Intern. Cong., Series 55, 1588 (1963).

PDAC tumors are heavily reliant on nutrient-scavenging pathways such as autophagy and the lysosome – a degradative organelle that plays an essential role in the digestion and recycling of diverse ...

His lab has focused significant efforts on the mTOR pathway. This signaling network ... This latter work led to the discovery of the direct sensors for leucine and arginine and identified the lysosome ...

uhnresearch.ca Objectives Mammalian target of rapamycin (mTOR) (a serine/threonine protein kinase) is a major repressor of autophagy, a cell survival mechanism. The specific in vivo mechanism of mTOR ...

In mammals, autophagosome formation, a central event in autophagy, is initiated by the ULK complex comprising ULK1/2, FIP200, ATG13, and ATG101. However, the structural basis and mechanism of the ULK ...

Increased nitric oxide (NO) production was detectable in 4-week-old NZB/W F1 mice (see online supplementary figure S3E). mTOR activity was not consistently elevated at 4 weeks of age but it was ...

Long-term, low-dose cannabis treatment has been shown to reverse brain aging and enhance cognitive abilities in mice by modulating the protein switch mTOR, which plays a critical role in cellular ...

Subsequent membrane expansion and fusion mediated by Atg5-Atg12-Atg16L1 and LC3-II lead to autophagosome formation, followed by fusion with lysosomes to form functional autophagy units ... by ...

Moreover, Rnf144b −/− mice exhibited a higher survival rate upon EMCV infection compared with wild-type mice. The ubiquitin-proteasome and autophagy-lysosome pathways represent the classic protein ...