【导读】作为癌症中最常见的基因改变，超过一半的人类癌症具有导致转录失活的p53突变。然而，p53如何调节免疫景观以创造免疫逃逸的生态位，仍然难以捉摸。团队发现癌症干细胞（CSCs）建立了白细胞介素34（IL-34）编排的生态位，以促进p53灭活肝癌的 ...

【导读】结直肠癌(CRC)是全球癌症相关死亡率的第二大原因，而p53作为一种被广泛认可的肿瘤抑制因子，促进了CRC的发展。USP36属于去泛素化酶家族，参与多种癌症的进展。然而，在结直肠癌中USP36调控p53信号通路的潜在分子机制尚不清楚。9月29 ...

【导读】SETD8是一种在几种癌症中过度表达的甲基转移酶，它使H4K20和其他非组蛋白靶点(如PCNA或p53)单甲基化。9月28日，西班牙国立癌症研究中心研究人员在期刊《Cell Death&Disease》上发表了研究论文，题为“SETD8 ...

Hereditary breast cancers are caused by germline mutations, which are genetic mutations inherited at conception and so called ...

While a study suggests that spike proteins found in the COVID-19 vaccine can affect a tumor suppressor gene, it is not proof ...

Colorectal cancer (CRC) stands as the second most common cause of cancer-related mortality globally and p53, a widely recognized tumor suppressor, contributes to the development of CRC.

Researchers at the University of Michigan Rogel Cancer Center have recently uncovered a novel subtype of aggressive prostate ...

When researchers at the University of Michigan Rogel Cancer Center first identified a new subtype of aggressive prostate ...

我国是全球癌症最高发的国家之一，其中肺癌是“头号杀手”。根据组织病理学特点不同，肺癌可分为非小细胞肺癌和小细胞肺癌。肺腺癌是非小细胞肺癌最常见的组织学亚型，是全球癌症相关死亡的主要原因，是一个巨大的公共卫生负担。尽管靶向和免疫治疗取得了一定进展，但肺 ...

Despite higher levels of mRNA encoding SG proteins during pancreatic tumorigenesis, this study finds no SG formation in ...

Data show that p300 KAT inhibitor KB-9558 was highly selective against human papillomavirus (HPV) oncoproteins E6 and E7, and therefore drove ...

Discover the potential of chronotherapy, a groundbreaking approach to cancer treatment that aligns chemotherapy with your ...