【导读】作为癌症中最常见的基因改变，超过一半的人类癌症具有导致转录失活的p53突变。然而，p53如何调节免疫景观以创造免疫逃逸的生态位，仍然难以捉摸。团队发现癌症干细胞（CSCs）建立了白细胞介素34（IL-34）编排的生态位，以促进p53灭活肝癌的 ...

【导读】结直肠癌(CRC)是全球癌症相关死亡率的第二大原因，而p53作为一种被广泛认可的肿瘤抑制因子，促进了CRC的发展。USP36属于去泛素化酶家族，参与多种癌症的进展。然而，在结直肠癌中USP36调控p53信号通路的潜在分子机制尚不清楚。9月29 ...

【导读】SETD8是一种在几种癌症中过度表达的甲基转移酶，它使H4K20和其他非组蛋白靶点(如PCNA或p53)单甲基化。9月28日，西班牙国立癌症研究中心研究人员在期刊《Cell Death&Disease》上发表了研究论文，题为“SETD8 ...

While a study suggests that spike proteins found in the COVID-19 vaccine can affect a tumor suppressor gene, it is not proof ...

Hereditary breast cancers are caused by germline mutations, which are genetic mutations inherited at conception and so called ...

Colorectal cancer (CRC) stands as the second most common cause of cancer-related mortality globally and p53, a widely recognized tumor suppressor, contributes to the development of CRC.

Researchers at the University of Michigan Rogel Cancer Center have recently uncovered a novel subtype of aggressive prostate ...

When researchers at the University of Michigan Rogel Cancer Center first identified a new subtype of aggressive prostate ...

我国是全球癌症最高发的国家之一，其中肺癌是“头号杀手”。根据组织病理学特点不同，肺癌可分为非小细胞肺癌和小细胞肺癌。肺腺癌是非小细胞肺癌最常见的组织学亚型，是全球癌症相关死亡的主要原因，是一个巨大的公共卫生负担。尽管靶向和免疫治疗取得了一定进展，但肺 ...

A potential new treatment for an aggressive form of prostate cancer has shown promise in lab tests. American scientists have ...

Data show that p300 KAT inhibitor KB-9558 was highly selective against human papillomavirus (HPV) oncoproteins E6 and E7, and therefore drove ...

Discover the potential of chronotherapy, a groundbreaking approach to cancer treatment that aligns chemotherapy with your ...