Endocannabinoids in the brain play a key role in food intake and energy use. Modulating the action of these molecules could ...

Inhibition of GABAergic neurotransmission desynchronizes clock gene expression but does not affect circadian rhythms of GABA in the SCN Given the observed temporal discrepancy between presynaptic ...

Summary: Atomoxetine is a methylphenoxy-benzenepropanamine derivative with antidepressant activity and is thought to enhance noradrenergic function via selective inhibition of the presynaptic ...

This important study leverages the power of Drosophila genetics and sparsely-labeled neurons to propose a new model for neuronal injury signaling. The authors present convincing evidence to support ...

Targeting a brain enzyme called ABHD6 that degrades a key endocannabinoid molecule known as 2-AG could help fight obesity.

Researchers at CRCHUM found that targeting the enzyme ABHD6 in specific brain regions of mice reduces obesity without causing ...

A new study reveals that modulating endocannabinoids in the brain can reduce food intake and boost physical activity, ...

Endocannabinoids in the brain play a key role in food intake and energy use. Modulating the action of these molecules could help fight obesity, say researchers.

AA-LTP is weakly dependent on GABAergic inhibition, but most interestingly also ... Since we observed an effect of SR application on the amplitude of EPSCs (presynaptic GABA A Rs are known to modulate ...

Expert Rev Endocrinol Metab. 2010;5(5):653-662.