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科学家开发PROTAC药物,可降解13种常见KRAS突变
今日,邓迪大学和勃林格殷格翰的科学团队在《科学》杂志发文,为泛KRAS对策提供了一个新选项。研究者们开发了针对KRAS的蛋白水解靶向嵌合体(PROTAC)药物,可有针对性地降解17种常见KRAS突变中的13种。 根据体外研究数据,研究者认为降解KRAS相较抑制KRAS是一 ...
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