Medscape28d
Proinsulin-Transferrin Fusion Protein as a Novel Long-Acting Insulin Analog for the Inhibition of Hepatic Glucose Production
Proinsulin-transferrin (ProINS-Tf) fusion protein was evaluated for its in vivo pharmacokinetics, efficacy, and mechanism. Our previous studies have shown that ProINS-Tf was converted to active ...
Nature10d
Retuning the immune system: the future of type 1 diabetes therapy?
For example, it is thought that BHT-3021 works in the following way: the proinsulin that is encoded by the DNA plasmid is processed by antigen-presenting cells of the immune system. They present ...