c Includes CHD or CHD risk equivalent, 10-y risk >20%. d Includes ≥2 risk factors, 10-y CHD risk 10-20%. e Includes ≥2 risk factors, 10-y CHD risk <10%. f Includes 0-1 risk factors.
Data sources Randomised controlled trials (RCTs) comparing high-intensity statin therapy (atorvastatin 80 mg or rosuvastatin 20/40 mg) with moderate/mild statin treatment or placebo were derived from ...
Dosing a statin (rosuvastatin) every other day (EOD ... of patients were able to tolerate the EOD therapy (mean dose 5.6 mg) regimen for 4 ± 2.9 (mean ± SD) months. Mean LDL-C decreased 34.5 ...
Phase 1 results support proceeding to Phase 2 in patients with post-bariatric hypoglycemia (PBH), which is expected to begin in 2H 2025 Phase 1 trial in healthy volunteers showed MBX 1416 was generall ...
In the MAD cohort, MBX 1416 appeared to increase GLP-1 within 60 minutes of a mixed meal tolerance test, suggesting a pharmacodynamic (PD) effect in healthy volunteers that may translate into a ...
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Specifically, rosuvastatin, atorvastatin, or simvastatin were used at doses corresponding to high-dose intensity. This corresponds to 20–40 mg for rosuvastatin and 40–80 mg for atorvastatin or ...
During the past 20 years, the percentage of patients with HF and preserved systolic function has ... to eplerenone or placebo in addition to standard medical therapy. Eplerenone (mean dose, 43 mg ...
Request permissions for this article. From the Saha Cardiovascular Research Center (C.W., A.D., H.S.L.), University of Kentucky, Lexington. Department of Physiology ...