A new paper from Elham Azizi's lab and collaborators has been accepted for publication in Genome Research, marking a ...

Prenatal skin atlas and hair-growing skin organoids could inform on new approaches to enable scarless wound healing or ...

【导读】转移级联反应是一个多方面且高度侵袭的过程，是导致死亡的主要原因。在转移过程中，循环系统中静止癌细胞的存活至关重要，但由于缺乏普遍接受的静止癌症模型，科学界的理解受到限制。2024年10月11日，北京大学肿瘤医院、苏州大学肿瘤研究所詹启敏院士团 ...

发表在《细胞》杂志上的一项新研究挑战了单细胞数据集不会有隐私泄露风险的假设。 获取公开可用的人类单细胞基因表达数据集或scRNA-seq数据集，大大增强了研究人员对复杂生物系统和各种疾病词源的理解。然而，可获得性的增加引起了人们对捐赠细胞的个人隐私的更大关注，以及他们的私人健康细节在未经同意的情况下被分享的可能性。 先前对这些隐私泄露的研究主要集中在大量基因表达数据共享上，其中基因的平均表达水平是 ...

A research team from Beihang University and Tsinghua University has demonstrated that integrating learnable neural units with ...

using a compendium of scATAC-seq experiments paired with bulk ATAC-seq or scRNA-seq from the same cells to evaluate accuracy, bias, robustness, and scalability. Kallisto, bustools and kb-python ...

This work presents a valuable finding on how the interplay between transcription factors SOX2 and OCT4 establishes the pluripotency network in early mouse embryos. Despite the high quality of the data ...

近日，上海礼升生物韩欣欣、蔡春晖，复旦大学附属妇产科医院曹琦等人在 MedComm 期刊发表了题为：P atient-derived ovarian cancer organoid carries immune microenvironment ...

通过全面的单细胞RNA测序（scRNA-seq）进一步分析表明，同时用CD3ζ和TLR4在体内编程CAR-M可以显著促进巨噬细胞从M2促癌表型向M1促炎表型的转变，通过干扰NF-κB通路以上调PD-L1和MHC I表达。同时，该研究还发现，CAR-M细胞重塑了免疫抑制性的肿瘤微环境，从而提高了 ...

Program for Cancer and Cell Biology, Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences; Peking University International Cancer Institute; and State Key Laboratory ...

The human brain, comprising billions of diverse neurons intricately organized into highly efficient neural networks, remains the only known system ...