What is the rationale behind this decision? Readers may wonder, especially given that RNA abundance in single nuclei is generally lower than that in single cells. This concern also applies to ...

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Gut-Brain Connection. People who have CD83+ microglia in their brains also have HCMV (top left) and IgG4 (top right) in their ...

Single-cell sequencing has revolutionized our understanding of immune cell heterogeneity in the brain, identifying unique subpopulations with distinct transcriptomic signatures (30). In AD, ...

After 4 days, we performed tartrate-resistant acid phosphatase (TRAP) staining and determined the amount of OCs (TRAP positive and three or more nuclei ... RNA-seq library by using TruSeq SR RNA ...

Milenkovic. The study was possible thanks to a new technology called nanopore direct RNA sequencing, which permits the direct analysis of rRNA molecules with all its modifications. "It allows us ...

"We conducted an extensive study using single-nucleus RNA sequencing data on 600,000+ nuclei from five brain regions representing the stereotypical progression of AD pathology," said Das.