Here we look back at one of its key reactions: strain-promoted azide–alkyne cycloadditions (SPAAC). Owing to its robustness, simplicity and applicability to living systems, SPAAC continues to ...

信使核糖核酸(messenger ribonucleic acid, mRNA)是一种极具潜力的治疗药物, 在免疫学、肿瘤学、疫苗和先天性代谢疾病等研究领域具有广阔前景。但由于其自身不稳定且易被核酸酶降解所以需要高效的递送载体。脂质纳米颗粒(lipid nanoparticle, LNP)具有易于配制、稳定性高 ...

Base editors chemically convert one nucleotide base to another. The development of the first base editor eight years ago marked a major leap forward toward the use of genome-editing technologies ...

School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China Institute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen 518132, China ...