Rapa’s approach yields a T cell product with a phenotype with anti-cancer effects, including: promotion of Th1/Tc1 cytokine secretion while eliminating regulatory T cells; elimination of ...

By Pooja Toshniwal Paharia Study reveals that moderate fever temperatures (39°C) improve metabolism, proliferation, and ...

【导读】最近的研究探索了去甲基化药物(5-azacytidine, Aza)治疗一系列疾病的潜力。然而，Aza对动脉粥样硬化患者的治疗效果尚不清楚。9月20日，南京医科大学与陕西省人民医院研究人员合作在期刊《Cell ...

▎药明康德内容团队编辑  几乎每个人都有过发烧的经历，在被流感病毒等病原体感染后，身体出现一系列反应，发冷、乏力、肌肉酸痛，同时体温升高。有一种流传广泛的说法认为，发烧是免疫系统正在发挥作用的体现，可以帮助我们对抗病原体。然而，在《科学》子刊Science ...

This valuable study reports on a novel role of PD-1 in early T cell differentiation, showing that PD-1 stimulation impairs Th2 differentiation more effectively than that of Th1, with implications for ...

Fever temperatures rev up immune cell metabolism, proliferation and activity, but they also -; in a particular subset of T cells -; cause mitochondrial stress, DNA damage and cell death, Vanderbilt ...

To enhance a particular T cell phenotype, culture conditions can be adjusted. For instance, Th1 needs IL-12, Th2 needs IL-4, Tregs need TGF-β1, and Th17 needs IL-6. > 95 % as determined by SEC-HPLC.

Autoimmune pancreatitis (AIP) is a clinical condition characterized by inflammation of the pancreas, caused by the body's ...

In a major potential step toward personalized therapy for atopic dermatitis, data suggest early, late, and no clinical ...

But the researchers also made an unexpected discovery -; that a certain subset of helper T cells, called Th1 cells, developed mitochondrial stress and DNA damage, and some of them died.

Elicera Therapeutics describes how CAR T cells armed with neutrophil-activatingprotein can improve cancer therapy by inducing ...