This study provides important insights into the regulation of a retained intron in the mRNA coding for OGT, a process known to be regulated by the O-GlcNAc cycling system, and highlights the ...

Requests for official transcripts received by December 13, 2024 will be processed before the holiday closure. Transcript requests received during the holiday closure will only be processed upon our ...

Gene regulation refers to the mechanisms that ... binding of proteins to specific DNA elements to regulate transcription, or mechanisms that modulate translation of mRNA. Response strategies ...

Del-brax (AOC 1020) for FSHD showed a 50% reduction in DUX4 gene expression ... marking a promising advancement for exon 44 skipping therapies. I reiterate my “Strong Buy” due to its pipeline ...

President-elect Donald Trump, welcome back to Meet the Press. PRESIDENT-ELECT DONALD TRUMP: Thank you very much. KRISTEN WELKER: Thank you so much for being here. You are the first president since ...

"In synthetic biology or gene therapy, transcription factors with off-target effects can cause some concerning unintended consequences, so, by understanding and being able to manipulate mechanisms ...

For example, an sQTL of the TCHP gene has been identified ... the high average sequencing depth and the "exon painting" effect (incomplete reverse transcription along with stochastic mRNA cleavage ...

2024) Pluripotency is thought to have emerged with the appearance of multicellular animals some 700 million years ago, so it stands to reason that transcription factors associated with stem cell ...

Dec. 4, 2024 — Researchers have uncovered a serious side effect of using the CRISPR-Cas gene scissors. A molecule designed to make the process more efficient destroys parts of the ...

Combined, our findings provide significant insight into the mechanisms underlying RBP-mediated gene expression regulation in response to growth ... AS events across all four treatment comparisons by ...