DNA trinucleotide repeat expansions are known ... the door to effective therapies for this and other trinucleotide repeat expansion disorders.

The work was reported in Cell. Two recent studies have also highlighted the significance of repeat expansion disorders (REDs). There are about fifty disorders that have been linked to tandem repeats.

In collaboration with Harry Orr's group (University of Minnesota), we determined that the mutation responsible for SCA1 is an expansion of a CAG trinucleotide repeat encoding glutamine in the protein ...

These expansions are the most common cause of inherited neurological conditions, known as repeat expansion disorders (REDs). The study's results showed that REDs are up to three times more ...

The disease is caused by a CAG trinucleotide repeat expansion in the coding region of exon 1 of the huntingtin (HTT) gene, which results in production of mutant HTT protein (mHTT) with an ...

The paper is titled "A phenome-wide association study of methylated GC-rich repeats identifies a GCC repeat expansion in AFF3 as a significant cause of intellectual disability." The study reveals ...

24, 2023. Analysts all seem to agree the grouping’s expansion means something significant – probably to do with China. Some see the new BRICS as heralding a new currency, or even world order.

First clinical data of VO659 demonstrated 28% mean reduction in CSF mutant HTT at day 85 in HD patients in 40 mg dose cohort with an effect after the first dose No sustained increase in CSF ...

The double-digit increase in transaction volumes processed in the 12-month trading period was driven by a combination of domestic growth and international expansion. Fonix has successfully cracked ...

The size of a business can be measured in terms of its sales, its value, or the number of employees it has. In order to expand, the business needs to increase one or more of these elements.