这种效应或许与白血病细胞重编程其代谢从而在恶劣的肿瘤微环境中茁壮成长（其可塑性）有关，而来自mtDNA突变的代谢压力或许也会增加细胞的可塑性。因此，当杂合子小鼠暴露于一点代谢压力时就会增加对不同癌基因转化的易感性，而在纯合子小鼠中，其基本上是关闭的， ...

Mutations that happen throughout a person’s life may contribute to disease more than we realized. In the summer of 2018, ...

The pair had helped identify a still-unnamed disease, which they had tied to a particular gene and to a particular somatic mutation—a genetic change that had not been passed down from a parent ...

A pivotal study has provided unprecedented insights into the genetic architecture of sweet oranges, highlighting the critical ...

Mutations can be grouped into two main categories based on where they occur: somatic mutations and germ-line mutations. Somatic mutations take place in non-reproductive cells. Many kinds of ...

More information: GaRyoung Lee et al, Prediction of metabolites associated with somatic mutations in cancers by using genome-scale metabolic models and mutation data, Genome Biology (2024). DOI ...

Dr. Abdel-Wahab’s research focuses on the role of genomic alterations in the pathogenesis of hematopoietic malignancies. The Abdel-Wahab lab focuses on understanding and targeting the somatic ...

St. Jude researchers reveal that moderate levels of mitochondrial DNA mutations boost leukemia growth by increasing metabolic ...