这种效应或许与白血病细胞重编程其代谢从而在恶劣的肿瘤微环境中茁壮成长（其可塑性）有关，而来自mtDNA突变的代谢压力或许也会增加细胞的可塑性。因此，当杂合子小鼠暴露于一点代谢压力时就会增加对不同癌基因转化的易感性，而在纯合子小鼠中，其基本上是关闭的， ...

Recent research led by UTHealth Houston scientists has uncovered two genes associated with variants linked to epilepsy, which ...

Loss of the Y chromosome (LOY) in men, a dynamic mutation linked to aging, impairs immune function and increases risks of ...

A pivotal study has provided unprecedented insights into the genetic architecture of sweet oranges, highlighting the critical ...

Mutations that happen throughout a person’s life may contribute to disease more than we realized. In the summer of 2018, ...

Mitochondria are vital to energy production in cells and so play a key role in fueling cancer growth. However, how ...

St. Jude researchers reveal that moderate levels of mitochondrial DNA mutations boost leukemia growth by increasing metabolic ...

When the Precision Medicine Initiative was launched in 2015, it completely transformed patient care in oncology. Now, ...

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, ...

Olaparib is under clinical development by AstraZeneca and currently in Phase II for Malignant Mesothelioma. According to GlobalData, Phase II drugs for Malignant Mesothelioma have a 42% phase ...

This year’s most-viewed articles and videos on myelodysplastic syndromes (MDS) explored patient quality of life, risk factors ...