The addition of taxanes, and subsequently trastuzumab in HER2-overexpressing patients, to anthracyclines further improved their efficacy in several studies involving high-risk early breast cancer ...
This Review examines the evidence for rechallenging with both anthracyclines and taxanes, and highlights the issues that need to be examined in the context of future clinical trials.
Some cytotoxic anticancer drugs may boost an immunogenic molecular signal of apoptosis. Why did anthracyclines have this property, whereas many other chemotherapeutic agents did not? It appears ...
19 Doxorubicin is an anthracycline produced by the Streptomyces species. Anthracyclines have several mechanisms of action, the most important of which is interaction with topoisomerase II.