[11] The small G protein RAS, the protein kinase RAF, and PI3K have central roles as intracellular mediators of EGFR signaling (Fig. 1) Overexpression of EGFR may be detected in up to 90% of ...

Here the authors identify that a microprotein HDSP derived from the long non-coding RNA HOXA10-HOXA9 is overexpressed in gastric cancer and forms a positive feedback loop with MECOM to drive EGFR ...

Summit Therapeutics Inc. (NASDAQ: SMMT) ("Summit," "we," or the "Company") today announced that we have completed enrollment ...

and novel agents (e.g. tirapazamine, EGFR inhibitors and other targeted agents) with radiotherapy will be examined. This article is part one of two articles. In the subsequent article, the general ...

The company is targeting its RPPA-based testing to biopharma firms as well as for clinical trial work and to clinicians to help guide therapy in cancer patients.

RHO signalling is a cell signalling pathway by which extracellular or intracellular stimuli promote activation of the small GTPase RHO. Cell adhesion, mechanical stress and membrane receptor ...