Treatment options for patients with glioblastoma multiforme (GBM), the most common form of malignant gliomas, now include anti-angiogenic therapy after failure of standard multi-modality treatments.
Somatic monoallelic single nucleotide variants in the genes that encode isocitrate dehydrogenase (IDH) 1 and 2 are found in a large subset of diffusely infiltrating gliomas and subsets of acute ...
More information: Jingyi Wu et al, Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas, Nature Cancer (2024). DOI: 10.1038/s43018-024-00865-3 Provided by Broad ...
Siren Biotechnology Inc. has unveiled its lead asset, SRN-101, for the treatment of high-grade gliomas. The FDA has granted orphan drug and rare pediatric disease designations to SRN-101 for ...
Researchers from Northwestern University and Yale University have presented new preclinical data for KL-50, a small molecule under investigation for the treatment of glioblastoma. KL-50 was designed ...
These tumors are now categorized by WHO as separated from adult brain tumors and based on their distinct molecular features, including K27M and G34R mutations in the histone H3.3. These tumors, ...