2024 年 10 月 3 日，北京大学基础医学院罗建沅教授联合北京大学人民医院申占龙教授和丽水市中心医院纪建松教授课题组联合在 PNAS 杂志上发表了题为 “LAMTOR1 ablation impedes cGAS degradation ...

In mammals, autophagosome formation, a central event in autophagy, is initiated by the ULK complex comprising ULK1/2, FIP200, ATG13, and ATG101. However, the structural basis and mechanism of the ULK ...

However, its exact molecular mechanism of action remains unknown. Our aim was to prove melatonin's short‐ and long‐term neuroprotection and investigate its role on the AMPK (AMP‐activated protein ...

Immunohistochemistry techniques were used to quantify the expression levels of amyloid-beta 42 (Aβ42) and microtubule-associated protein 1A/1B-light chain 3 (LC3) in hippocampal tissues, while western ...

Long-term, low-dose cannabis treatment has been shown to reverse brain aging and enhance cognitive abilities in mice by modulating the protein switch mTOR, which plays a critical role in cellular ...

Here, we show that RNF144B specifically interacts with MDA5 and promotes K27/K33-linked polyubiquitination of MDA5 at lysine 23 and lysine 43, which promotes autophagic degradation of MDA5 by p62.

The Key Protein p62 A protein called p62 plays a central role in maintaining cellular health by supporting autophagy and helping cells get rid of harmful proteins like alpha-synuclein. However, ...

Moreover, SHD could upregulate the levels of AMPK, microtubule associated protein light chain 3 (LC3), autophagy related protein 5 (ATG5) and Beclin1, downregulate the levels of mTOR, p62, promoted ...

Notably, the emergence of SMC-derived luminal myofibroblasts—in both mice and patients with KD, Takayasu’s arteritis and Giant Cell arteritis—coincided with activation of the mechanistic target of ...