To define the effects of exon 3 deletion on Mecp2 expression, we compared RNA and protein from mutant and control brains. Northern-blot analysis detected a slightly smaller Mecp2 transcript at a ...

DNA 甲基化作为一种重要的表观遗传修饰，在癌症、遗传学、表观遗传学和干细胞研究等领域具有广泛的应用价值[1]。作为 DNA ...

Researchers at Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas ...

Researchers have uncovered how loss of the MeCP2 protein triggers early molecular changes leading to Rett syndrome, a severe ...

10. Tighten caps, shake well and leave in the fume hood for 1-2 min for phase separation. 11. Using a pasteur pipette, carefully transfer the upper hexane phase into small 2 ml glass vials; this ...

DNA methylation is the covalent addition of methyl groups to DNA bases, typically the cytosine of CpG dinucleotides. It is catalyzed by methyltransferase enzymes using a S-adenosyl methionine ...

Of 22 pesticides associated with prostate cancer incidence, 4 were also associated with prostate cancer death.