At initiation of parenteral prostacyclin therapy, 62% of patients had intermediate-high COMPERA 2.0 risk status, whereas at ...

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Normally, these nasty effects are kept in check by another chemical called prostacyclin. But prostacyclin is made, in part, with the help of Cox-2 enzymes -- the enzymes that drugs like Celebrex ...

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1 Academic Unit of Child Health, Sheffield Children's Hospital, Sheffield, UK 2 Paediatric Intensive Care Unit, Sheffield Children's Hospital, Sheffield, UK Correspondence to Dr David King, Academic ...

Meloxicam is an enolcarboxamide with preferential COX-2 activity. Studies conducted on experimental models and human tissues indicate that meloxicam is a more potent inhibitor of COX-2 than COX-1 ...

Table 1. Suggested strategies for analgesic/anti-inflammatory treatment and cardiovascular prevention among patients with inflammatory disease and different levels of risk of vascular events ...

16 PTGS2, also known as cyclooxygenase 2b, is the key inducible enzyme in biosynthesis of prostaglandins, prostacyclin and thromboxanes. Together with NO synthase, this enzyme is over-expressed in ...