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18 天
肝细胞Hedgehog信号通路抑制通过促进衰老加速MASLD疾病进程
MASLD相关肝硬化和其他代谢功能障碍性疾病发生风险随年龄增长而增加。主要原因是,随年龄增长而累积的表观遗传修饰使细胞难以再生,并引发衰老相关分泌表型。MASLD可诱导肝细胞DNA损伤和衰老,其严重程度和衰老肝细胞的数量密切相关。然而,肝细胞衰老的 ...
腾讯网
21 天
一款被淘汰的抗癌药,如何成为艾滋病治疗的救星?
霍维茨先将脱氧胸苷(Thymidine) 3位上的羟基进行磺酰基化,然后再与一些亲核试剂反应,就合成出来一组新的核苷酸类似物,这其中就包括带有叠氮 ...
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