This is an important study using a combination of optogenetics and calcium imaging to provide insight into the function of the cholinergic input to the prelimbic cortex in probabilistic spatial ...

“It allows individuals to unlearn behaviors when rules or circumstances change—a process heavily reliant on acetylcholine signaling.” By combining optogenetics—which uses light to control CIN activity ...

Discover groundbreaking research on how chronic alcohol use affects cognitive flexibility and brain signaling circuits, ...

Alcohol use disorder (AUD) affects about 400 million people worldwide and is a leading cause of serious illnesses such as ...

Texas A&M researchers found that chronic alcohol use disrupts cholinergic interneuron (CIN) firing patterns in the brain, ...

By combining optogenetics—which uses light to control CIN activity—and fiber photometry—which involves genetically engineered biosensors to detect real-time release of acetylcholine while su ...