Aims: To determine the maximum tolerated dose (MTD), safety and anti-tumor activity of afatinib combined with docetaxel in advanced cancer. Patients & methods: The MTD was determined from dose ...

The CHRYSALIS-2 study (NCT04077463) evaluated the combination of amivantamab (Rybrevant), an EGFR-MET bispecific antibody, ...

Afatinib (trade name: Giotrif) has been approved since April 2016 for the treatment of adults with locally advanced or metastatic non-small cell lung cancer (NSCLC) of squamous histology who have ...

RAS信号在驱动正常生理细胞增殖中起着重要作用，该信号通路的失调通常发生在肿瘤发生过程中。事实上，该通路的改变，特别是RAS蛋白本身的改变，对许多癌症具有深远的影响。因此，在过去几十年中，人们做出了大量的努力来开发靶向RAS的药物，然而其突变 ...

It serves as another demonstration on batch removal and image contrast conversion of the CytoMAD model. In this experiment, H2170 were treated with 3 drugs of different mechanism of action (MoA) (i.e.

2020; Närhi et al., 2018). HER2-mutant microfluidics-embedded PXDOT models were used to study therapeutic responses to gefitinib, afatinib and neratinib (all at 0.5 μM) over 96 h using dual ...

The Innovation scorecard estimates report is produced by NICE and published by NHS Digital. The report shows the trend in prescribing of NICE recommended first-generation (gefitinib and erlotinib) and ...

Non-small-cell lung cancer (NSCLC) treatment has led to improved efficacy and compliance due to individual tailoring of the therapeutic options and the use of strategies based on both clinical ...

There are many cancer drugs and cancer drug combinations. They have individual side effects. The list includes chemotherapy, hormone therapies, targeted cancer drugs, immunotherapy drugs and ...