Ke Hou generated a compound that prevents tau aggregation in the murine brain, but the potential Alzheimer’s disease therapy ...

Amyloid plaques comprising tangled fibrils of misfolded proteins are well-known drivers of neurodegenerative diseases including Alzheimer’s and Parkinson’s disease, but they are also present ...

It is caused by the buildup of toxic proteins called amyloid fibrils throughout the body. The amyloid fibrils damage tissues ...

Immune cells in the brain called microglia can partially break down large amyloid plaques characteristic of Alzheimer's disease by latching on to them, forming a sort of external stomach and releasing ...

Such amyloid beta fibrils are one of the hallmarks of all forms of Alzheimer's disease, although their structures vary according to the disease variety. Discovering the structures of amyloid ...

Preclinical studies have shown AT-02 is able to bind to multiple amyloid types and can induce macrophage mediated amyloid phagocytosis and removal. The Food and Drug Administration has granted Orphan ...

Amyloid beta, TDP-43, and SOD-1 PFFs. These products support and accelerate the development of reliable neurodegenerative disease models. Tau TAU-H5115 Human Tau-441/2N4R Pre-formed Fibrils ...