Immune cells in the brain called microglia can partially break down large amyloid plaques characteristic of Alzheimer's ...

Ke Hou generated a compound that prevents tau aggregation in the murine brain, but the potential Alzheimer’s disease therapy ...

Immune cells in the brain called microglia can partially break down large amyloid plaques characteristic of Alzheimer's disease by latching on to ...

The kinetics of fibrillization in dilute aqueous solutions of the protein was monitored as a function of incubation time using the dye thioflavin T, which binds to amyloid fibrils but not to ...

As many as 23 different precursor proteins to the formation of amyloid have been described in man. These may deposit themselves in a fibrillar matrix within selected tissues. Fibrils are formed when ...

Transthyretin amyloid cardiomyopathy occurs when TTR tetramers dissociate into misfolded monomers that deposit as myocardium amyloid fibrils. Ex vivo studies found that acoramidis, a high-affinity TTR ...

Crafting a unique and promising research hypothesis is a fundamental skill for any scientist. It can also be time consuming: ...

The researchers also conducted other experiments with randomly chosen keywords, which produced various original hypotheses about more efficient biomimetic microfluidic chips, enhancing the mechanical ...

Light chain amyloidosis is caused by plasma cells in the bone marrow that produce more light chain proteins than heavy chain proteins, which ultimately leads to the deposition of amyloid fibrils ...

近日，2024年诺贝尔化学奖得主David Baker进行了一场题为《De Novo Protein Design》的精彩演讲，站在科研最前沿为我们揭开了谜底：AI for Science究竟有哪些应用场景，能带来哪些实际价值。 David ...