Immune cells in the brain called microglia can partially break down large amyloid plaques characteristic of Alzheimer's disease by latching on to them, forming a sort of external stomach and releasing ...

Preclinical studies have shown AT-02 is able to bind to multiple amyloid types and can induce macrophage mediated amyloid phagocytosis and removal. The Food and Drug Administration has granted Orphan ...

EMA’s human medicine committee recommends marketing approval for acoramidis for treatment of transthyretin amyloid cardiomyopathy: Berlin Monday, December 16, 2024, 13:00 Hrs [I ...

Light chain amyloidosis is caused by plasma cells in the bone marrow that produce more light chain proteins than heavy chain proteins, which ultimately leads to the deposition of amyloid fibrils ...

What did we learn during Summit’s bonus year of scientific discovery? Here are five sample projects with impactful results. Lighting the way to a new Alzheimer’s treatment Amyloid fibrils are protein ...

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Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-Shimoadachi, Sakyo-ku, Kyoto 606-8501, Japan ...

Immunoglobulin light chain amyloidosis (AL) shares with multiple myeloma (MM) the overproduction of one clonal light chain (LC), but whereas in MM patients LC molecules remain soluble in circulation, ...

Both ALλ(CLA) and ALκ(TAL) appeared ultrastructurally comparable (Figures 1A, B). Addition of ThT resulted in similar fluorescence emission at 490 nm, characteristic of the presence of amyloid fibrils ...

Amyloid fibrils appear in many neurodegenerative diseases, and scientists are eager to understand how they form and spread. But amyloids—clumped aggregations of misfolded proteins—can be difficult to ...