A breakthrough in understanding how a single-cell parasite makes ergosterol (its version of cholesterol) could lead to more ...

A breakthrough in understanding how a single-cell parasite makes ergosterol (its version of cholesterol) could lead to more ...

The compound is a novel azole with activity about 100-fold more against ... CD101 will be an intravenous antifungal, with the potential for higher drug exposures than currently marketed echinocandins ...

Scientists have identified strains of one of the world’s most dangerous fungal pathogens, already resistant to our most ...

Many drugs, such as monoclonal antibodies and ... remain important for IFDs such as mucormycosis. In 1981, the first azole antifungal, the diazole ketoconazole, was introduced to the market ...

Drugs that cause QT prolongation and are metabolized ... Neurotoxicity with concomitant vincristine; reserve azole antifungals for those who have no alternative treatment options.

Labor & delivery. Pregnancy (Cat.D), nursing mothers: not recommended. See Contraindications; other azole antifungals: not recommended. Potentiates CNS depression with alcohol, psychotropics ...

The efficacy and safety of a combination therapy including caspofungin and another antifungal (either AMB or an azole) in a small ... without a major concern about drug-related side effects.

Luckily, some antifungals require little dosing ... However, if history follows the other azole compounds, children will require more drug for a similar response. The echinocandin class is no ...

Therefore, azole antifungals targeting the CYP5122A1 enzyme ... That's the main discovery in this study—we figured out the true drug target in leishmania. You really need to hit this new enzyme ...