A breakthrough in understanding how a single-cell parasite makes ergosterol (its version of cholesterol) could lead to more effective drugs for human leishmaniasis, a parasitic disease that afflicts ...

Many drugs, such as monoclonal antibodies and ... remain important for IFDs such as mucormycosis. In 1981, the first azole antifungal, the diazole ketoconazole, was introduced to the market ...

A breakthrough in understanding how a single-cell parasite makes ergosterol (its version of cholesterol) could lead to more ...

The compound is a novel azole with activity about 100-fold more against Aspergillus fumigatus ... CD101 was highly effective, similar to amphotericin B, in this survival experiment. CD101 will be an ...

A breakthrough in understanding how a single-cell parasite makes ergosterol (its version of cholesterol) could lead to more ...

Scientists have identified strains of one of the world’s most dangerous fungal pathogens, already resistant to our most ...

The findings, reported in Nature Communications, also solve a decades-long scientific puzzle that’s prevented drugmakers from successfully using azole antifungal drugs to treat visceral ...

The efficacy and safety of a combination therapy including caspofungin and another antifungal (either AMB or an azole) in a small ... without a major concern about drug-related side effects.

Luckily, some antifungals require little dosing ... However, if history follows the other azole compounds, children will require more drug for a similar response. The echinocandin class is no ...