This mainly included quercetin derivatives, kaempferol derivatives ... In this study, the flavones in blueberry fruit mainly included the derivatives of apigenin, luteolin, chrysoeriol, tricin, and ...

The treatment design will mimic the failed clinical trials in lung cancer patients where anti-CD38 antibodies were combined with anti-PD-1/anti-PD-L1 inhibitors. In vivo administration of murine ...

It can only be used: after 3 or more lines of treatment (including an immunomodulatory drug, a proteasome inhibitor and an anti‑CD38 antibody), and when the multiple myeloma has got worse on the last ...

This is the first ever report on the long-term treatment with a Bcl-2 inhibitor at high doses. Prof. Sikander Ailawadhi commented, "For previously heavily treated R/R MM, in combination with Pd, ...

The methods used are deficient: they are largely reliant on the use of chemical inhibitors and do not adequately support the conclusions. S. aureus bacteria, which enter host cells of the same cell ...

Aeovian Pharmaceuticals Inc. has prepared tricyclic fused imidazole compounds acting as ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) inhibitors reported to be useful for the treatment of ...

Version of Record: This is the final version of the article. This manuscript describes soluble Uric Acid (sUA) as an endogenous inhibitor of CD38, affecting CD38 activity and NAD+ levels both in vitro ...

ChoKα inhibition is known to activate AMPK (8). In addition, the AMPK activator quercetin is known to inhibit ChoKα (19), suggesting that ChoKα may lie upstream of the AMPK pathway that activates ...

Highlights include the most recent data on CD38-directed monoclonal antibodies ... including the role of novel complement inhibitors in clinical practice. The discussion will also provide ...