The faithful replication and segregation of the DNA is dependent on the existence of checkpoints that monitor the accuracy of these events and prevent cell-cycle progression when problems arise.

The cell must also pass through a series of checkpoints that ensure conditions are favorable for division. In order to move from one phase of its life cycle to the next, a cell must pass through ...

CHK1 is important for the activation of S, G2 checkpoints in response to DNA damage and replicative stress and is involved ... and concept for the project that CHK1 inhibition was therapeutically ...

A review discussing the therapeutic potentials of NK cell biology has been published in the journal Frontiers of Medicine. This exhaustion is influenced by immune checkpoint receptors, which are ...

This exhaustion is influenced by immune checkpoint receptors, which are inhibitory cell surface receptors that can suppress antitumor immunity. Notably, intracellular checkpoint molecules within ...

A review discussing the therapeutic potentials of NK cell biology has been published in the journal Frontiers of Medicine. Natural killer (NK) cells are pivotal in the innate immune response ...