Regulatory T (T Reg) cells are essential for maintaining peripheral tolerance, preventing autoimmunity and limiting chronic inflammatory diseases. However, they also limit beneficial responses by ...

In this manuscript, Yao et al. present solid evidence to show that MnMYL3 may serve as a receptor for NNV via macropinocytosis. This manuscript is valuable for understanding the molecular mechanisms ...

However, chronic TLP also induces homeostatic proliferation of CD8 T CM cells, which express high levels of chemokine receptors that enhance tumor tropism, thereby increasing the number of PD-1− CD8 T ...

A study investigated and compared the tissue tropism of a 2004 H5N1 strain isolated from a fatal human case and the 2024 bovine strain of H5N1 that is currently circulating in mice and found that ...

Aswathy Ammothumkandy receives funding from American Epilepsy Society, and California Institute for Regenerative Medicine. Michael A. Bonaguidi receives funding from the National Institutes of ...

As women age, they produce an increasing number of “killer” immune cells, which hunt down and destroy infected cells. This discovery, and the fact that the same isn’t true of men ...

Voyager’s capsid discovery platform, TRACER (“Tropism Redirection of AAV by Cell-type-specific Expression of RNA”), applies directed evolution to AAV capsids to find vectors optimized for ...

The Company's fully integrated cell and gene therapy cGMP manufacturing facility served as the manufacturing ... Abeona's novel, next-generation AAV capsids are being evaluated to improve tropism ...

investigate differences in tissue tropism. LLC-PK cells were obtained from Guangdong Wen’s Foodstuffs Group Co. Ltd (Guangdong, China) and cultured in DMEM medium (Hyclone, USA) supplemented with 10% ...